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[DOI] [PubMed] [Google Scholar] 14.Ozaras R., Tahan V., Aydin S., Uzun H., Kaya S., Senturk H

Weight loss naturally slows due to decreased basal metabolic rate as body mass reduces, metabolic adaptation where the body conserves energy more efficiently, and hormonal changes affecting appetite signals

There is significant evidence that the answer to the second question is yes, with the caveat that patients should know that these drugs arent meant to be taken forever

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Another use one that is increasingly popular is as a weight loss drug

How does retatrutide compare to semaglutide and tirzepatide